Alternate Treatments For ED: Trimix

TriMix refers to a mixture of three drugs that produce an erection upon being injected into the shaft of the penis.

A standard TriMix drug combination might consist of Papaverine, Phentolamine, and Alprostadil (PGE), but different drugs can be substituted in and out in varying quantities on a patient by patient basis.

TriMix is generally explored as an ED treatment option if a patient doesn't have success with common first line ED treatments such as prescription medications.

How does TriMix Work?

The drugs that make up TriMix produce a vasodilating effect upon being administered. When injected into the proper area along the shaft, the corpus cavernosum, parts of the penis relax, dilate, and become filled with blood, leading to an erection.

The combination usually starts to work in about 5 to 20 minutes. It is adviseable to wait around 10-30 minutes before you have sex, and the erection should last about an hour.

Is it safe?

When considering TriMix as a treatment option, there are several safety considerations. It is important to discuss TriMix with your doctor before taking it. Let your doctor know if you have medical problems such as:

  • Problems with your penis, such as curvature or birth defects
  • Bleeding problems
  • Penile infection
  • Red or itchy penis
  • Conditions that cause thickened or slower blood flow
  • If you take a blood thinner, or if you bruise easily
  • Peyronie's disease

There are some potential side effects of TriMix to be aware of. If you decide to take TriMix, call your doctor immediately if you have any of the following:

  • Curving of the penis with pain during an erection
  • Erection lasts for 4 to 6 hours
  • Swelling or pain in the testes
  • Bleeding or spotting from the urethra

Are men satisfied with TriMix treatment?

In terms of erection quality, roughly 70% of men report being able to attain an erection suitable for sex after injecting TriMix. However, there are many complaints regarding the treatment due to the inconvenience of how it is administered.

Additionally, much like with oral prescription medications, there is no certainty that TriMix will be a suitable long term treatment method for any given patient's erectile dysfunction due to the fact that it doesn't address the core bloodflow related problems that are often the root cause of ED.

“ doesn't address the core bloodflow related problems that are often the root cause of ED...”

If you are interested in pursuing other treatment options for ED, learn more about the other common ones such as prescription pills, or prosthetic devices.

For a natural and noninvasive alternative, learn about the services we provide at Multnomah Medical.

1. Bearelly P, et al. (2019). Long-term intracavernosal injection therapy: Treatment efficacy and patient satisfaction.
2. Erectile dysfunction: Trimix injections. (n.d.).
3. Penile injection therapy. (2018).

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